Extrapolation of Radiation-Induced Cancer Risks from Nonhuman Experimental Systems to Humans

This report reviews the scientific issues associated with the extrapolation of radiation-induced cancer risks from nonhuman experimental systems to humans. The basic principles of radiation effects at the molecular and cellular level are examined with emphasis on comparisons among various species including humans. These comparisons among species are then continued for cancers of similar cell types in the same organ system. Risk estimates are made from an observed level of effect as a function of organ dose. The major organ systems are individually considered. Extrapolation models are reviewed and include external and internal radiation exposures.
Content:
• Front Matter
• Preface
• Table of Contents
1. Executive Summary and Recommendations
• 2. Introduction
3. History of Extrapolation: Nonhuman Experimental Systems to Humans
4. Tissue and Organ Differences Among Species with Emphasis on the Cells of Origin of Cancers
5. Radiation Effects at the Molecular and Cellular Levels
6. Extrapolation Models
7. Summary
• Glossary
• Symbols and Acronyms
• References
• The NCRP
• NCRP Publications
• Index